Dr. M. Sharon Stack received her PhD degree in Biochemistry from the University of Louisville, completed post-doctoral training in biochemical pathology at Duke University Medical Center, and served for several years as a Research Assistant Professor in Pathology at Duke.

In 1994, she joined the faculty in the Department of Cell & Molecular Biology at Northwestern University where she rose through the ranks to tenured Professor. While at Northwestern, Dr. Stack was also Program Leader of the Tumor Invasion, Metastasis and Angiogenesis Program of the NCI-designated RH Lurie Comprehensive Cancer Center (RHLCCC) and a member of the RHLCCC Executive Committee.

She joined the University of Missouri in 2007 as Professor and Vice Chair for Research in the Department of Pathology and Anatomical Sciences. She is currently (since 2011) Professor of Chemistry and Biochemistry and the Ann F. Dunne and Elizabeth Riley Director of the Harper Cancer Research Institute, University of Notre Dame.

Stack Lab Research Overview

The ability to invade host tissues and metastasize is the major cause of cancer-related death. During tumor invasion, metastasizing cells disrupt normal cell-cell and cell-matrix contacts and acquire a migratory, invasive phenotype. Thus modulation of cell-cell and cell-matrix adhesive events likely plays a critical role in tissue remodeling during tumor progression. Subsequent alterations in cellular architecture mediated by modified extracellular matrix (ECM) attachments induce expression of proteinases that degrade ECM proteins, facilitating migration through the modified tissue to establish metastatic foci and removing matrix constraints that normally limit proliferation.

“Either do it right, or don’t do it at all.”

– Pete Stack, ND Class of ’51

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Human Papillomavirus (HPV)-Associated
Oropharyngeal Cancer
(Hardcover & Kindle)

Daniel L. Miller (Editor)
M. Sharon Stack (Editor)

Ovarian Cancer
Cancer Treatment and Research
(Hardcover)

M. Sharon Stack (Editor)
David A. Fishman (Editor)

Curriculum Vitae – Dr. M. Sharon Stack

Director Harper Cancer Research Institute

Professor of Chemistry & Biochemistry
University of Notre Dame

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